Alterations of Gefitinib Pharmacokinetics by Co-administration of Herbal Medications in Rats

Kwon Yeon Weon,Min Gi Kim,Soyoung Shin,Tae-Hwan Kim,Sang Hoon Joo,Eunsook Ma,Seok Won Jeong,Sun Dong Yoo,Yu Seok Youn,Beom Soo Shin

Alterations of Gefitinib Pharmacokinetics by Co-administration of Herbal Medications in Rats

2018

Kwon Yeon Weon
Min Gi Kim
Soyoung Shin
Tae-Hwan Kim
Sang Hoon Joo
Eunsook Ma
Seok Won Jeong
Sun Dong Yoo
Yu Seok Youn
Beom Soo Shin

Objective To evaluate the potential pharmacokinetic interactions of the anticancer agent gefitinib (Iressa®) and the oriental medications Guipi Decoction (归脾汤, GPD, Guibi-tang in Korean) and Bawu Decoction (八物汤, BWD, Palmul-tang in Korean).

Keywords:

Diabetes mellitus
Alternative medicine
Medicine
Herb-drug interactions
Decoction
Gefitinib
Pharmacokinetics
Pharmacology
co administration
Cmax
Delayed time
Area under the curve

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