Direct Comparison of Anti-Interference Property for Bimetallic PtAu, PtIr, and PtRu Nanoparticle Catalysts in Amperometric Detection for H2O2 Based Biosensors

Mediator-less and anti-interference catalyst potentially provides a new sensing platform to the nextgeneration biosensors. For amperometric measurement, electrode fouling and poor specificity to co-existing electro-active species have remained to be major challenges. Chloride anions and many interferents are known to highly oxidize at moderate potential, imposing directly on generated H2O2 detection. Because the generated H2O2 is a key product to monitor physiological activity in biosensors (e.g. glucose sensors, cholesterol sensors, and tumor/cancer sensors), this effect primarily causes false increasing current, misleading in determination of enzymatic reactions. Thus, a design of catalyst to address this fundamentally important concern would be highly desirable to any amperometric biosensors.