Super-resolution ultrasound in peripheral nerve blood flow imaging

Many diseases and trauma are accompanied by peripheral neuropathy. The pathological changes of the microvessels are important indicators of peripheral nerve injury and regeneration. However, there is a lack of effective imaging methods on the microvascular imaging of the peripheral nervous system in vivo. Contrast-enhanced ultrasound has been explored to evaluate peripheral nerve blood perfusion, while it cannot provide explicit vasculature. Super-resolution ultrasound (SRUS) imaging technology has been widely developed in recent years, which provides a promising and powerful tool for investigating microvessels. In this work, we applied the SRUS and demonstrated its feasibility in the peripheral nervous blood flow imaging.