EFFECT OF ROSUVASTATIN THERAPY ON ARTERIAL WALL CHANGES IN CHILDREN AND ADOLESCENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA: RESULTS FROM THE CHARON STUDY

Gisle Langslet,Marjet J.A.M. Braamskamp,Brian W. McCrindle,David Cassiman,Gordon A. Francis,Claude Gagné,Daniel Gaudet,Katherine M. Morrison,Albert Wiegman,Traci Turner,Elinor Miller,Joel S. Raichlen,Paula G. Martin,Evan A. Stein,John J. P. Kastelein

EFFECT OF ROSUVASTATIN THERAPY ON ARTERIAL WALL CHANGES IN CHILDREN AND ADOLESCENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA: RESULTS FROM THE CHARON STUDY

2014

Gisle Langslet
Marjet J.A.M. Braamskamp
Brian W. McCrindle
David Cassiman
Gordon A. Francis
Claude Gagné
Daniel Gaudet
Katherine M. Morrison
Albert Wiegman
Traci Turner
Elinor Miller
Joel S. Raichlen
Paula G. Martin
Evan A. Stein
John J. P. Kastelein

Familial hypercholesterolemia (FH) accelerates carotid intima media thickness (c-IMT) which is a surrogate marker for cardiovascular (CV) disease. This study investigated the effect of rosuvastatin on c-IMT in FH children 6-17 years compared with unaffected (non-FH) matched siblings. Trial number: [

Keywords:

Intima-media thickness
Rosuvastatin
Disease
Surrogate endpoint
Familial hypercholesterolemia
Cardiology
Diabetes mellitus
Internal medicine
Endocrinology
Medicine
arterial wall
trial number

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