Dipole-Dipole Interaction in Antibody Solutions: Correlation with Viscosity Behavior at High Concentration

Shubhadra N. Singh,Sandeep Yadav,Steven J. Shire,Devendra S. Kalonia

Dipole-Dipole Interaction in Antibody Solutions: Correlation with Viscosity Behavior at High Concentration

2014

Shubhadra N. Singh
Sandeep Yadav
Steven J. Shire
Devendra S. Kalonia

Purpose The purpose of this study was to investigate the contribution of the dipole moment to overall protein-protein interactions and viscosity of a monoclonal antibody MAb1.

Keywords:

Dipole
Antibody
Nuclear magnetic resonance
Viscosity
Analytical chemistry
Monoclonal antibody
Chemistry
high concentration
pharmacology toxicology
self association
dielectric relaxation spectroscopy
Chromatography
Molecular physics

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