Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: relation to clinical symptoms

Abstract Objective Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms. Methods We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N=60) and control Alzheimer’s disease (AD, N=60) and healthy elderly (Nold, N=60) seniors were taken from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources. Results As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB “controls”, the DLB patients with 1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p Conclusions Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients. Significance Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies.