Novel Types of Bicyclonucleosides: Isoxazolidinofuranosylthymines

Abstract Novel types of bicyclonucleosides (3, 9) bearing a 3′,5′-epoxyimino (or iminoepoxy) bridge have been prepared using intramolecular Mitsunobu reactions. Contrarily to close analogs, also of the β-D-threo configuration but oxidizable to nitrones (2, 2′) which were found active against HIV, the new compounds exhibited no anti-HIV activity.