Solid-state Characterization of Bifonazole - beta-cyclodextrin Binary Systems. II

Continuing our previous researches, this paper presents the studies regarding the solid state characterization of binary systems between antimycotic bifonazole and beta-cyclodextrin. The binary systems were prepared in two (bifonazole : beta-cyclodextrin) molar ratios, 1:2 and 1:3, using the physical mixture and the kneading method. In order to characterize the solid state interaction between the two components, hot-stage microscopy, differential scanning calorimetry, X-ray diffractometry and Fourier-transformed infrared spectroscopy were used. The analysis performed indicate a molecular interaction between the components due to a partially encapsulation of bifonazole into the cyclodextrin cavity.