Cytotoxic Triterpenoid Saponins from the Stems of Gordonia longicarpa
2013
Nine new triterpenoid saponins named longicarposides A–I ( 1 – 9 ),
together with three known saponins ( 10 – 12 ), were isolated from
the stems of Gordonia longicarpa . The structures of the saponins were
elucidated by a combination of 1D and 2D NMR techniques, mass spectrometry,
and chemical methods. They were characterized to be oleanane-type saponins
with sugar moieties linked to C-3 of the aglycone. Cytotoxic activities of
these saponins were evaluated against five human tumor cell lines (HCT-8,
Bel-7402, BGC-823, A549, and A2780) by using the MTT in vitro assay.
Compounds 5, 7, 8, 10 , and 11 exhibited potent cytotoxic
activity with IC 50 values of 1.42–8.42 µM, while 6, 9 , and
12 showed selective cytotoxic activity toward the tested cell
lines.
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