PROBLEMS OF AUTOIMMUNITY AND AUTOINFLAMMATION IN RHEUMATOLOGY: LESSONS FROM CORONAVIRUS DISEASE 2019 (COVID-19)

According to modern concepts, human immuno-inflammatory diseases, depending on the prevailing mechanisms of immunity activation, are divided into two main categories: autoimmune and auto-inflammatory, related to the activation of acquired and congenital immunity respectively. Autoimmunity and autoinflammation are particularly prevalent in immunoinflammatory rheumatic diseases (IMRD), deciphering of the pathogenesis, expanding diagnostic capabilities and developing new treatment methods are among the priorities of medicine in the XXI century. The development of various immunopatological disorders, that determine the prognosis in patients with COVID-19 served as the basis for the drug repurposing of anti-inflammatory drugs previously specially developed for the treatment of IMRD. This is a vivid example of the demand for new medical technologies for the treatment not only of IMRD, but also of COVID-19 and, in the future, of other virus-induced immune diseases.