Non-destructive sampling device for extraction of a marker

Method and device for extraction of markers, comprising: introducing a sample into a removable support basket placed in the housing of a cell of an extraction device provided with a flexible membrane and immersing the tissue sample in a liquid previously introduced into the housing, followed by hermetic closing of the extraction cell and application of a pressure cycle on the flexible membrane for a period of 1 to 5 minutes at a frequency between 1 and 2 Hz. Then, total or partial recovery of the liquid immersing the sample after the pressure cycle and detection of the markers present in the liquid.