Association of cellular and subcellular calcification with phosphorylated tau in the brains of Alzheimer's disease patients.

Deposition of tau-tangles is an early marker for the development of Alzheimer's disease (AD). Here we show that these aggregates of phosphorylated tau protein are associated with the calcification of cell nuclei and cell projections, especially in the middle temporal, superior temporal and parahippocampal gyri. This calcification is related to the aetiology of the disease, shedding new light on the mechanisms involved in AD and potentially providing a new detection method for AD progression. ### Competing Interest Statement The authors have declared no competing interest.