Correlation between protein oxidation and antioxidant system and individual typological particularities of rat behavior in norm and post-stress psychopathology

We studied the oxidative modification of proteins and the activity of components of antioxidant systems in the blood serum of rats with different types of behavioral activity in the norm and during post-stress psychopathology. After testing of behavior, animals were separated into four groups. We found that the groups in the norm have different levels of oxidative modification of proteins and activity of superoxide dismutase. To generate post-stress psychopathology, we used water-immersion stress in combination with immobilization. After the development of post-stress psychopathology, we observed changes in the indices studied. It is possible to conclude that different changes in oxidative modification of proteins and the activity of the antioxidant system occur during the development of post-stress psychopathology in rats with different individual typological particularities of behavior.