SYNTHESIS AND REACTIVITY OF METHYL 3-ACYL-6-AMINO-4-ARYL-5-CYANO-4 H -PYRAN-2-CARBOXYLATES

By treating arylidenemalononitriles with methyl 2,4-dioxobutanoates, derivatives of 4 H -pyrans - methyl 3-acyl-6-amino-4-aryl-5-cyano-4 H -pyran-2-carboxylates - are obtained, which are novel, promising structural components for the synthesis of carbo- and heterocycles. The reactions of these pyrans with sulfuric and hydrochloric acids, acetic anhydride, and alcohols have been studied. Novel methods have been developed for the preparation of substituted derivatives of cyclopentenone, pyrano[2,3- d ]-pyrimidine, 5-oxo-3-phenylpentanoic acid, and nicotinic acid nitrile. Authors: V. P. Sheverdov, A. Yu. Andreev, O. V. Ershov, O. E. Nasakin, V. A. Tafeenko, and V. L. Gein. English Translation in Chemistry of Heterocyclic Compounds , 2012, 48 (7), pp 997-1005 http://link.springer.com/article/10.1007/s10593-012-1091-2