OP-138 : Prevalence and predictive factors of obstructive sleep apnea in Korean patients with interstitial lung disease

Background: Interstitial lung diseases (ILD) are chronic progressive lung disease with high morbidity and mortality. In recent studies, the prevalence of obstructive sleep apnea (OSA) in patients with ILD have been reported to be high. However, prevalence and predictive factors in Korean patients are not well defined. The aim of this study was to evaluate prevalence and predictive factors of OSA in Korean patients with ILD. Methods: Clinical data were retrospectively analyzed in 86 patients with ILD enrolled from December 2017 to April 2019 at Haeundae-Paik hospital. OSA was monitored with portable device (SOMNOcheck micro, level 4, Weinmann Medical Technology, Hamburg, Germany), and was defined by apnea-hypopnea index (AHI) above 5 per hour of sleep. Results: The median follow up period was 7 months. The mean age was 69.8 years and 64% were men. Among total ILD, idiopathic pulmonary fibrosis (IPF) was the most common (66.3%), followed by connective tissue disease (CTD) associated ILD (17.4%), and organizing pneumonia (5.8%), respectively. Forty six patients (53.5%) were diagnosed with OSA and IPF patients had more frequent OSA (64.9% vs. 31.0%, p = 0.003) than those with other ILD. Old age (OR 1.11, 95% CI 1.04-1.19, p = 0.002), high weight (OR 1.05, 95% CI 1.01-1.10, p = 0.012) and diabetes mellitus (OR 4.03, 95% CI 1.26-12.91, p = 0.019) were independent risk factors for OSA in multivariate logistic regression analysis. Survival was not different between ILD patients with and without OSA (14.1 months ± 29.3 vs. 12.1 ± 13.9 months, log-rank test, P = 0.819). Conclusions: The prevalence of OSA in Korean patients with ILD was high (53.5%), and was higher in IPF patients compared to those with other ILD. Old age, high weight and diabetes mellitus mean high risk of OSA in patient with ILD.