Phenolic compounds with anti-inflammatory effects from Knema furfuracea

Abstract Knema furfuracea is a tropical evergreen plant, which belongs to Myristicaceae family. Phytochemical investigation on the twigs and leaves of K. furfuracea led to the isolation of 11 phenolic compounds, including a new flavonoid knemavane A (1). These compounds belong to flavonoids, lignans, and anarardic acids. Biological evaluation of the inhibitory activities of compounds 1–11 against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages showed that compounds 1 (IC50 = 13.79 μM), 2 (IC50 = 9.28 μM), and 6 (IC50 = 15.14 μM) were active.