Current methodologic approaches to the study of various delayed effects of pesticides

: Studies on the possibilities of origination of remote sequelae (embryotoxic and teratogenic, gonadotropic, mutagenic, carcinogenic, alterations in cardiovascular system, etc) under the effect of the wide application of pesticides in the practice is one of the most important aspects of the present-day toxicology. Numerous of our studies in that field are directed to the pesticides, to fungicides in particular, the greater part of them being with mechanisms of biological activity, triggering changes in DNA synthesis and disturbances in cellular respiration. The results from our experimental studies are presented in the communication, with an aspect of alterations in the gonads, embryotoxicity and teratogenicity, of representatives of various groups of chemical preparations for plant protection. The eventual use of those data in the prognosis of potential risk for humans is discussed. Model conditions are proposed for a more thorough assessment and more accurate determination of threshold levels of effect with a view to their utilization in hygienic standardization.