Response by Mittal et al to Letter Regarding Article, “Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury”

If the intent of the letter by Gagat and Grzamka is to point out that actin cytoskeleton remodeling induces vascular barrier disruption is an important phenomenon, we fully agree.1 Its clear tight junctions have a role in regulating endothelial barrier in the brain endothelial cells, although their role is less important in the continuous endothelium such as in the heart and lungs.1 Recent knock out mouse model studies2,3 (including ours4) have provided compelling evidence that adherens junctions or VE-cadherin junctions are important in regulating leukocyte transmigration and …