Disruption of the Mouse Cyclooxygenase 1 Gene

We recently reported the characteristics of mice deficient in cyclooxygenase (COX) 1 (Langenbach et al., 1995) and COX-2 (Morham et al., 1995). This chapter will summarize the known characteristics of COX-1 deficient mice and describe some future studies utilizing these mice which will lead to a better understanding of the physiological functions of the COX’s and their roles in the therapeutic and toxic effects of NSAIDs (non-steroidal anti-inflammatory drugs).