Design, synthesis, conjugation and reactivity of novel trans,trans-1,5-cyclooctadiene-derived bioorthogonal linkers

Beatrice Longo,Chiara Zanato,Monica Piras,Sergio DallAngelo,Albert D. Windhorst,Danielle J. Vugts,Massimiliano Baldassarre,Matteo Zanda

Design, synthesis, conjugation and reactivity of novel trans,trans-1,5-cyclooctadiene-derived bioorthogonal linkers

2020

Beatrice Longo
Chiara Zanato
Monica Piras
Sergio DallAngelo
Albert D. Windhorst
Danielle J. Vugts
Massimiliano Baldassarre
Matteo Zanda

The tetrazine/trans cyclooctene (TCO) inverse-electron-demand Diels-Alder (IEDDA) reaction is the fastest bioorthogonal “click” ligation process reported to date. In this context, TCO reagents have...

Keywords:

Cyclooctene
Chemistry
Bioorthogonal chemistry
Tetrazine
Succinimidyl carbonate
Combinatorial chemistry
design synthesis
Serum albumin
Reagent
1,5-Cyclooctadiene

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