Rhabdomyosarcoma of the cervix in sisters: with review of the literature

Objectives. Pediatric embryonal heterologous rhabdomyosarcoma of the cervix is a rare tumor. Methods. We present an interesting clinico-pathologic situation of two sisters presenting with pediatric embryonal heterologous rhabdomyosarcoma of the cervix. Results. Pediatric embryonal heterologous rhabdomyosarcomas of the cervix are relatively uncommon. After a Pubmed search from 1952 to present, to our knowledge, this is the only report involving sisters presenting with this disease. Treatment has been extrapolated from collaborative groups such as Intergroup Rhabdomyosarcoma Study (IRS) Group so that optimal management may be achieved. Conclusions. We urge continued reporting of these rare tumors to enhance understanding if there may be a genetic component associated with them.