Synthesis of 2-Methyl 16-Membered Macrolide Derived from Tylosin.
2006
To improve the metabolic stability of a 16-membered macrolide, 2-methylated derivatives of desmycosin were synthesized. Among these derivatives, 2β-methyldesmycosin retained antibacterial activity and showed improved stability in rat serum compared to desmycosin.
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