Human papillomavirus infection among Uyghur women with cervical intraepithelial neoplasia in Xinjiang area.

To obtain the baseline data of Uyghur women for human papillomavirus (HPV) vaccination in Xinjiang.The authors analyzed the infection and distribution characteristics of HPV genotypes in genital tracts among Uyghur women with cervical intraepithelial neoplasia (CIN) in Urumqi of Xinjiang. A total of 1,431 eligible cases involved in this trial. All cervical samples from these patients were detected for HPV genotype.High-risk HPV was identified in 24.7% of 979 histologically confirmed normal samples and 89.2% of 452 samples with CIN (p 1) are higher-risk HPV types in Uyghur women with CIN in Urumqi of Xinjiang. There was no association between multiple infection and cervical lesion progression (0.31, PR < 1).Except for the common HPV-16, -58, -31, -33, -18 in Xinjiang, HPV-68 and HPV-39 may be the oncogenic subtypes to Uyghur female with CIN in Xinjiang. Distinguishing these HPV subtypes may have implications for future cervical screening strategies and vaccine implementation. Multiple infections were not association with an increased risk of high-grade cervical neoplasia.