New procedure for s? Synthesis of ivabradine and addition salts of a? Pharmaceutically acceptable acid.
2010
Synthesis method of the compound of formula (VII) in racemic or optically active form: wherein R represents a hydrogen atom or a methyl group, wherein the compound of formula (VIII): is reacted with the compound of formula (IX ), in racemic or optically active, in free base or salt: wherein R is as defined above, in the presence of a salt of a transition metal or a lanthanide, in a solvent, to obtain the compound of formula (X), in racemic or optically active form: which is converted into the compound of formula (VII) by a hydride donor agent.
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