Sugary Drink Consumption and Subsequent Colorectal Cancer Risk: The Japan Public Health Center-Based Prospective Cohort Study.

Background: Most studies examining the associations of sugary drink consumption on colorectal cancer risk have been conducted in Western populations. Methods: This study consisted of 74,070 participants in the Japan Public Health Center–based Prospective Study who completed a food frequency questionnaire (1995–1999). The participants were followed until December 2013 to investigate the associations between sugary drink consumption and colorectal cancer risk using Cox proportional hazards regression models. Results: Among the 74,070 participants, mean age was 56.5 years at baseline, with a mean body mass index (BMI) of 23.5 and a mean daily consumption of 286 mL/day for men and 145 mL/day for women. During a follow-up of 15 years, 1,648 colorectal cancer cases were identified. No overall greater risk of colorectal cancer was observed among men [multivariable HR = 0.84; 95% confidence of interval (CI), 0.70–1.02; ≥254 mL/day vs. nonconsumers] and women (HR = 1.20; 95% CI, 0.96–1.50, ≥134 mL/day vs. nonconsumers). Sugary drink consumption was associated with colon cancer among women (HR = 1.36; 95% CI, 1.03–1.78, ≥134 mL/day vs. nonconsumers). HRs for proximal colon cancer among women who consumed sugary drinks, as compared with nonconsumers, were 1.47 (95% CI, 1.03–2.10) for sugary drink consumption less than 134 mL/day, and 1.45 (95% CI, 1.01–2.09) for at least 134 mL/day. Conclusions: In this large prospective cohort of Japanese with a moderate sugary drink consumption level and low prevalence of obesity, we observed a 36% increased risk of colon cancer in women. Impact: Our findings highlight the importance of subsite- and sex-specific investigation.