Failure of PUVA in lichen myxoedematosus: acceleration of associated multiple keratoacanthomas with development of squamous carcinoma.

Summary We report a case of lichen myxoedematosus/scleromyxoedema based on IgG-kappa para-proteinaemia and associated with multiple keratoacanthomas. With PUVA therapy there was little change in the scleromyxoedema; however, the growth of keratoacanthomas was accelerated, and squamous carcinoma developed in one lesion.