Proteasome inhibition aggravates tumour necrosis factor-mediated bone resorption

Heterozygous human tumour necrosis factor α transgenic (hTNFαtg) mice and wild-type littermates were intravenously injected with 0.75 mg/kg bortezomib or phosphate buffered saline twice a week. Mice were weekly assessed for clinical signs of arthritis. After 6 weeks of …