Continuous Feeding-Blending in Pharmaceutical Continuous Manufacturing

Pharmaceutical continuous manufacturing has steadily progressed from the proof of concept to the pilot and industrial production in the past two decades, some of which have recently been approved by the US Food and Drug Administration (FDA), resulting in a greater demand on experience in process design and operation in pharmaceutical continuous manufacturing. Unlike many of the individual unit operations that are themselves continuous operations, such as roller compaction, tableting, etc., and have been well studied previously, only the characterization of a continuous feeding-blending system will be discussed in detail in this chapter, which undergoes the most substantial change with a transition from batch to continuous manufacturing.