Multiparametric assessment of the anti‐glioma properties of OKN007 by magnetic resonance imaging
2010
Purpose:
To demonstrate that OKN007, a disulfonyl derivative of phenyl-tert-butyl nitrone (PBN), has anti-glioma activity in the clinically relevant C6 rat glioma model using multi-parametric magnetic resonance imaging.
Materials and Methods:
Twenty-one rats were intracerebrally implanted with C6 cells and administered OKN007 or kept as controls. Animals were monitored with MRI at 7 Tesla (T), using morphologic, diffusion-weighted and perfusion imaging, followed by histology and Western blots of angiogenesis and inflammatory markers.
Results:
OKN007 was found to decrease tumor volumes and increase survival. The glioma tissues of OKN007-treated rats were found to have longitudinal apparent diffusion coefficients (ADCz) of 0.76 ± 0.06 × 10−3 mm2/s, similar to the contralateral tissue and significantly smaller than untreated gliomas (0.97 ± 0.13 × 10−3 mm2/s). They had higher perfusion rates (66 ± 4 mL/100 g·min) than untreated gliomas (26 ± 7 mL/100 g·min). All examined molecular markers were decreased in OKN007-treated rat gliomas, compared with elevated levels in untreated rats.
Conclusion:
MRI assessment was successfully used to monitor a decrease in tumor growth, and corresponding alterations in ADC and perfusion rates in rat C6 gliomas treated with the anti-glioma agent, OKN007. J. Magn. Reson. Imaging 2010;31:796–806. ©2010 Wiley-Liss, Inc.
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