Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population

The ADRA2B gene 301-303 I/D polymorphism is associated with various cardiovascular phenotypes. However, an association of genotypes with the timing structure of cardiac cycle remains unclear. The central hemodynamic parameters were assessed by pulse wave analysis in 63 healthy residents of Kola Peninsula (68 N) aged 27-65 years. The genotypes were determined by PCR. The multiple regression analysis adjusted for age, BMI, heart rate, and blood pressure revealed that II genotype carriers had higher values of augmentation index, ejection duration and lower SEVR than DD homozygotes. Further sex stratified analysis showed that the associations existed only in men whereas in women the differences only tended to be significant. It is concluded that in northern Russian population men carrying I allele have stiffer arteries, shorter diastole duration, impaired coronary perfusion and seem to be at higher risk for cardiovascular diseases than DD carriers.