Comparison of Clinical Findings of Positive- and Negative- Patients in Treadmill Test for Adults with Cardiovascular Events

This study was retrospectively designed to investigate differences in physiological variables between positive- and negative-patients in treadmill test for the diagnosis of patients with cardiovascular events and to confirm clinical usefulness of treadmill test. Total leukocyte and neutrophil counts, neutrophils/lymphocytes ratio and mean corpuscular volume were significantly higher, whereas platelet counts were lower in the positive group than in the negative group. Triglyceride and alkaline phosphatase concentrations were significantly higher in the positive group than in the negative group. The patients with abnormal levels of total cholesterol, high density lipoprotein cholesterol were higher in the positive group than in the negative group, but is reverse in hyperglycemia. High sensitivity C-reactive protein, erythrocyte sedimentation rate, lactic dehydrogenase, brain natriuretic peptide, creatinekinase-MB and troponine-I levels in the positive group were significantly greater than those of the negative group. P-, QRS- and T-axis in the EKG were higher whereas PR interval was shorter in the positive group than in the negative group. Most of cardinal symptoms were chest pain (57%) in the both groups. In final diagnosis angina pectoris (53% vs. 37%) and acute myocardial infarction (MI) (10% vs. 3%) were higher in the positive group than in the negative group. Cases of coronary artery angiography (CAG) and medication in the positive group were more than those of the negative group. Cases of normal CAG finding and observation in positive group were more than those of negative group. These data suggest that treadmill testpositive group had higher inflammation, myocardial injury, prevalence of angina pectoris and MI and that treadmill test has clinical usefulness. Also if adults have abnormal range of above mentioned clinical variables, treadmill test is recommended. However, treadmill test is not unique and the best tool for diagnosis of coronary artery disease because the patients with negative finding also had percutaneous coronary intervention and medications.