Neutrophil-lymphocyte relationship and its association with overall survival in advanced melanoma.

e20052 Background: The neutrophil-lymphocyte relationship (NLR) has been associated with lower survival rate in many tumors. The mechanisms underlying this association are poorly understood. An NRL > 4 would modify the inflammatory response, in which neutrophils suppress cytolytic activity of immune cells such as lymphocytes, activated T cells and natural killer cells, which correlate with a good prognosis in other tumors. A high NRL ( > 4) has also been associated to peri tumor infiltration by macrophages, interleukins, various cytokines (IL1-6-7-8-9-12) and interferons. Platelets can release some growth factors such as platelet-derived growth factor, platelet factor 4 and thrombospondin; therefore, the ratio of Platelet-lymphocytes (PLR) > 194 would be associated with worse prognosis. Our primary objective is to determine if values > 4 of the NLR are associated with worse overall survival (OS), at diagnosis of Advanced Melanoma. The secondary objective is to determine if the PLR are associated with OS a...