C H A P T E R 2 USE OF A DIALYZABLE SHORT-CHAIN PHOSPHOLIPID FOR EFFICIENT SOLUBILIZATION AND RECONSTITUTION OF INFLUENZA VIRUS ENVELOPES

Virosomes are reconstituted viral envelopes that can serve as vaccines and as vehicles for cellular delivery of various macromolecules. To further advance the use of virosomes, we developed a novel dialysis procedure for the reconstitution of influenza virus membranes that is easily applicable to industrial production and compatible with encapsulation of a variety of compounds. This procedure relies on the use of 1,2-dicaproyl-