Pressure Hyperalgesia in Hind Limb Suspended Rats

Spacefl ight and simulated microgravity often associate with pain and prediabetes. Streptozotocin (STZ)-induced moderate insu-linopenia rat models of prediabetes result in pressure hyperalgesia. The current study was designed to determine whether or not simulated micro-gravity induced by hind limb suspension (HLS) in rats lead to insulinope-nia and pressure hyperalgesia. Methods: Adult male rats were divided into HLS (