Efficacy and duration of botulinum toxin treatment for drooling in 131 children.
2010
Objective To address the efficacy of botulinum toxin and the duration of its effect when used on a large scale for the treatment of drooling in children with neurological disorders. Design Prospective cohort study. Setting Academic multidisciplinary drooling clinic. Patients A total of 131 children diagnosed as having cerebral palsy or another nonprogressive neurological disorder and who also have moderate to severe drooling. Intervention Injection of botulinum toxin to the submandibular glands. Main Outcome Measures Direct observational drooling quotient (DQ) (0-100) and caretaker visual analog scale (VAS) scores (0-100). Results A clinically notable response was found in 46.6% of children, reflected in a significant mean reduction in DQ from a baseline of 29 to 15 after 2 months and 19 after 8 months ( P P Conclusions Our study provides further support for botulinum toxin's efficacy for treatment of drooling in approximately half of patients for a median of 22 weeks. Further optimization of patient selection should be an area of attention in future studies.
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