Photodynamic diagnosis and white light imaging in treatment of non-muscle-invasive bladder cancer: A meta-analysis

Objective: To compare the efficacy of photodynamic diagnosis-assisted transurethral resection of bladder tumor (TURB) with conventional white light imaging-assisted TURB in primary non-muscle-invasive bladder cancer. Methods: Cochrance Libarary, PubMed, Embase, Wanfang Data, VIP Data and Chinese BioMedical Literature Database (CBM). The endpoints were 3-month, 9-month, 1-year, 2-year and 5-year biochemical failure rates. After evaluating the quality of the included literatures and extracting the data, the Meta-analysis was performed using Review Manager 5.3 software. The results were expressed as risk ratio (RR) with the corresponding 95% confidence interval (CI). Results: The final analysis included ten studies including 2 430 patients. The 9-month (RR: 0.80，95% CI: 0.69-0.93; P = 0.005), 1-year (RR: 0.65, 95% CI: 0.46-0.91; P = 0.010), 2-year (RR: 0.54, 95%: CI: 0.40-0.72; P < 0.001) and 5-year (RR: 0.76, 95% CI: 0.61-0.94; P = 0.010) biochemical failure rates were lower in patients who received photodynamic diagnosis-assisted TURB. Conclusion: The efficacy of photodynamic diagnosis-assisted TURB is superior to conventional white light imaging-assisted in efficacy of primary non-muscle-invasive bladder cancer in 5 years. DOI:10.3781/j.issn.1000-7431.2017.33.051