Abstract 12732: Coronary Stent Fracture Promotes Neoatherosclerosis Formation in-Stent Restenotic Neointimal Tissue After Drug-Eluting Stent Implantation

Introduction:Drug-eluting stent (DES) reduced the rates of in-stent restenosis and subsequent target lesion revascularization. However, stent fracture (SF) after DES implantation has become an important concern because of its potential association with restenosis and stent thrombosis. In addition, the pathogenic impact of SF on in-stent restenotic neointimal tissue components after DES implantation remains unclear. Hypothesis:We assessed the hypothesis that SF after DES implantation might promote neoatherosclerosis formation in restenosis lesions. Methods:We enrolled 41 consecutive patients with in-stent restenosis requiring revascularization after DES implantation between January 2008 and March 2014. In advance, we excluded the patients with recurrent restenosis, thrombotic lesions, and total occlusion. For evaluation of in-stent tissue components, integrated backscatter intravascular ultrasound (IB-IVUS) was performed. SF was defined as complete or partial separation of stent segments observed by using ...