Toll-like receptors in hematological malignancies

The Toll-like receptors are a kind of pattern recognition receptors, which are expressed in a variety of cells, playing an important role in innate immunity and subsequent acquired immunity. At the same time, they are also involved in the immunity, proliferation, apoptosis and other physiological processes of the cells. Toll-like receptors are also expressed in hematological malignancies and involved in the progress of tumor development, immune escape, resistance, which play a double-edged sword role. In this paper, basic knowledge of TLR molecule and study on hematological tumor were mainly reviewed, aiming to provide a train of thoughts for the treatment of hematologic malignancies. Key words: Toll-like receptors; Lymphoma; Leukemia; Tumor immunology