CRTC1-MAML2 gene fusion in G-CSF-secreting mucoepidermoid carcinoma: an indicator of favourable prognosis?

Mucoepidermoid carcinoma (MEC) is histologically characterised as low-, intermediate-, and high-grade [1]. Low-grade tumours rarely transform into high-grade tumours (dedifferentiation) [2, 3] and the latter very rarely produce granulocyte colony stimulating factor (G-CSF) [4, 5]. MEC harbours a characteristic t(11;19)(q21;p13) translocation; this rearrangement results from the fusion between exon 1 of the gene for CRTC1 (cyclic AMP/cyclic AMP-responsive element-binding protein-regulated transcription [...]