Tumor IGF-1 expression as a predictive biomarker for IGF1R-directed therapy in advanced pancreatic cancer (APC).

Milind Javle,Rachna T. Shroff,Gauri R. Varadhachary,Robert A. Wolff,David R. Fogelman,Priya R Bhosale,Xuemei Wang,Siddhartha Kar,Michael J. Overman,Sriram Sathyanarayanan,Mark Ayers,David J. Mauro,James L. Abbruzzese

Tumor IGF-1 expression as a predictive biomarker for IGF1R-directed therapy in advanced pancreatic cancer (APC).

2017

Milind Javle
Rachna T. Shroff
Gauri R. Varadhachary
Robert A. Wolff
David R. Fogelman
Priya R Bhosale
Xuemei Wang
Siddhartha Kar
Michael J. Overman
Sriram Sathyanarayanan
Mark Ayers
David J. Mauro
James L. Abbruzzese

4054 Background: IGF-1 up-regulates PC proliferation and invasiveness through activation of PI3K/Akt signaling pathway and down-regulates PTEN. We investigated IGF-1 expression in tissue and blood ...

Keywords:

Pancreatic cancer
Biomarker (medicine)
Insulin-like growth factor 1 receptor
PI3K/AKT/mTOR pathway
PTEN
Cancer research
Pathology
Akt/PKB signaling pathway
Medicine
predictive biomarker

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