薬物性胃粘膜障害の新たな評価法 (II) 乳糖混合による薬物胃粘膜直接障害の抑制

25 mg powder of NaCl or asprin mixed 25 mg of lactose was administered to the target on gastric mucosa by air flow carrying system through endoscope. NaCl or aspirin produced gastric ulcer, but, the mixture of lactose produced redness and/or erosions on target sites after 24 hour. The direct gastric mucosal injury of drug can be reduced the mixing of lactose.When powder of sucralfate mixed with NaCl or asprin was administered to gastric mucosa, redness and/or erosions lesions observed after 24 hour at target sites. Similarly, benexate hydrochloride β-cyclodextrin clathrate mixing NaCl or aspirin, produced redness and/or erosions lesions in canine stomach. The direct gastric mucosal injury can be reduced the mixing of sucralfate and/or benexate hydrochloride β-cyclodextrin clathrate which have direct effect to gastric lesions.