Секреция микромицетами протеиназ с активностью, подобной активности белков системы гемостаза

Using the chromogenic peptide substrates, proteolytic activity against proteins of the hemostasis system was studied in 9 micromycetes belonging to different ecological-trophic groups: phyto-, nemato-, myco- and entomopathogens, as well as human pathogens. It is shown that the investigated micromycetes secrete proteases with broad substrate specificity, but among them there are producers with pronounced both plasmin-like and urokinase (Arthrobotrys longa 1, Sarocladium strictum 203) also as TAP-like (Purpureocillium lilacinum k1) activity. The most active producer of proteases with fibrinolytic and activator activity to plasminogen activity was S. strictum 203 micromycete. The activity of proteinases formed by S. strictum 203 is about 50% of the fibrinolytic activity of plasminogen, which makes it a promising producer of fibrinolytic enzymes.