Asymmetrie des Planum temporale bei Zwillingen und Schizophrenen : Eine MRT-Untersuchung ()

Our aim was to examine a possible genetic determination of the disturbed cerebral lateralisation in schizophrenics. Morphometric data of planum temporale of monozygotic and dizygotic twins were evaluated for congruence and compared to first episode schizophrenics and normal controls (10 monozygotic and 10 dizygotic twin paris, 38 first episode schizophrenics, 15 normal controls). MRT: FLASH 3D T1-weighted sequence, 3 mm coronal slices. Postprocessing on workstation ISG Allegro with 3D-reconstruction of the temporal lobe and evaluation of the length and size of planum temporale and shape of Heschl's gyrus. In contrast to the normal left dominance of the size of planum temporale in twins and normal controls, schizophrenics showed a symmetry or slight dominance of right planum temporale. There was no significant difference in the asymmetry and non-congruence between monozygotic and dizygotic twins. The lack of similarity of planum temporale in monozygotic twins is an argument against genetic determination of size and shape and therefore its disturbed laterality in schizophrenics might be due to non-genetic, developmental factors.