Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas.

Sarika Heino,Shentong Fang,Marianne Lähde,Jenny Högström,Sina Nassiri,Andrew D. Campbell,Dustin J. Flanagan,Alexander Raven,Michael C. Hodder,Nadia Nasreddin,Hai-Hui Xue,Mauro Delorenzi,Simon J. Leedham,Tatiana V. Petrova,Owen J. Sansom,Kari Alitalo

Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas.

2021

Sarika Heino
Shentong Fang
Marianne Lähde
Jenny Högström
Sina Nassiri
Andrew D. Campbell
Dustin J. Flanagan
Alexander Raven
Michael C. Hodder
Nadia Nasreddin
Hai-Hui Xue
Mauro Delorenzi
Simon J. Leedham
Tatiana V. Petrova
Owen J. Sansom
Kari Alitalo

Somatic mutations in APC or CTNNB1 genes lead to aberrant Wnt signaling and colorectal cancer (CRC) initiation and progression via-catenin–T cell factor/lymphoid enhancer binding factor TCF/LEF tra...

Keywords:

tumor cells
Enhancer binding
Wnt signaling pathway
Colorectal cancer
Crypt
Cancer research
Somatic cell
Biology
Cell
Gene

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