N-[(Arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure

Four series of N-[(arylmethoxy) phenyl] compounds were prepared as leukotriene D 4 (LTD 4 ) antagonists. In the hydroxamic acid series, methyl 3-(2-quinolinylmethoxy) benzeneacetohydroxamate (Wy-48,422) was the most potent inhibitor of LTD 4 -induced bronchoconstriction. Compound also orally inhibited ovalbumin-induced bronchoconstriction in the guinea pig