Osteossarcoma e leucemia mielóide aguda: dois casos em crianças

A secondary neoplasia after chemotherapy often occurs in patients with Hodgkin's disease or brain tumors.1-4 There are a few cases of acute myeloid leukemia (AML) after osteosarcoma treatment reported in the literature. The authors report on two children who developed AML after being treated by chemotherapy for osteosarcoma. The first patient had a telangiectatic osteosarcoma; he was treated with carboplatin, ifosfamide, epirubicin and methotrexate and developed AML thirty eight months after therapy. The second patient had chondroblastic osteosarcoma; she was treated with cisplatin, doxorubicin and ifosfamide and she developed AML six months after treatment. The authors discuss the role of alkylating agents, topoisomerase II inhibitors and platinum compounds in the development of AML.