G-T haplotype established by rs3785889-rs16941382 in GOSR2 gene is associated with coronary artery disease in Chinese Han population

// Shuo Pan 1, * , Gong-Chang Guan 1, * , Ying Lv 1, * , Zhong-Wei Liu 1 , Fu-Qiang Liu 1 , Yong Zhang 1 , Shun-Ming Zhu 1 , Rong-Huai Zhang 1 , Na Zhao 1 , Shuang Shi 1 , Tomohiro Nakayama 2 and Jun-Kui Wang 1 1 First Department of Cardiology, People’s Hospital of Shaanxi Province, Xi’an, People’s Republic of China 2 Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan * These authors have contributed equally to this work Correspondence to: Jun-Kui Wang, email: wjk_sx@163.com Keywords: coronary artery disease, GOSR2, single nucleotide polymorphism, haplotype, genetic Received: March 06, 2017      Accepted: June 18, 2017      Published: July 17, 2017 ABSTRACT Objectives: The aim of the present study is to assess the association between the human GOSR2 gene and coronary artery disease using a haplotype-based case-control study in Chinese Han population. Methods: A total of 283 coronary artery disease patients and 280 controls were genotyped for the human GOSR2 gene (rs197932, rs3785889, rs197922, rs17608766, and rs16941382). Data were analyzed for three separate groups: the total subjects, men, and women. Results: For the total subjects, the frequency of the G-T haplotype established by rs3785889-rs16941382 was significantly higher in the coronary artery disease patients as compared to the control subjects ( P =0.009). Multiple logistic regression analysis also confirmed that the subjects with G-T haplotype established by rs3785889-rs16941382 (homozygote) were found having significantly higher chance suffering from coronary artery disease than the ones without this haplotype (OR=1.887, P =0.007). Conclusions: The G-T haplotype established by rs3785889-rs16941382 may be a risk genetic marker for coronary artery disease patients in Chinese Han population.