SYNTHESIS AND EVALUATION OF ANTIOXIDANT ACTIVITY OF SOME NEW BENZYLIDENE-THIAZOLIDINE-XANTHINE DERIVATIVES

SYNTHESIS AND EVALUATION OF ANTIOXIDANT ACTIVITY OF SOME NEW BENZYLIDENE-THIAZOLIDINE-XANTHINE DERIVATIVES (Abstract): The International Diabetes Federation reported that 246 million adults worldwide had diabetes mellitus and the prevalence of this syndrome was expected to increase continuously. Aim: To design new compound with potential antidiabetic and antioxidant activity. Material and methods: New benzylidene-thiazolidine derivatives (BT2a-2e) were obtained by condensation of xanthine-thiazolidine-4-one (TZ-4-one) with aromatic aldehydes. The synthesized compounds were characterized by spectral method (IR, H-NMR, C-NMR) and their antioxidant potential has been also evaluated. Results: The synthesized compounds have important antioxidant effects as compared to xanthine-thiazolidine derivatives. The most active compounds were those obtained by condensation with 4-dimethylaminobenzaldehyde (BT2c) and 4nitro-benzaldehyde (BT2e). Conclusions: The chemical modulations performed on the structure of TZD-4-one have a good influence on their antioxidant potential.