Synthesis of nanostructured oxides based on AlOOH and MgO and study of their cytotoxicity to normal and cancer cells

In the present work, toxicity of nanostructures based on aluminum hydroxide, magnesium oxide, and the influence of their combinations on morphofunctional characteristics of the normal and cancer cell lines was evaluated. Nanostructures were characterized by transmission (TEM) and scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), low temperature nitrogen adsorption, and dynamic light scattering method. It was found that low-dimensional aluminum oxide structures affect cancer cells rather than normal cells. It was established that magnesium oxide nanoparticles and nanostructured aluminum oxyhydroxide are more toxic for cancer cells than these nanostructures in combination in the same concentration. Probably, differences in the proliferative activity for both normal and cancer cells after contacting with synthesized nanostructures are provided by the changed cell microenvironment.