Immobilizing collagen type I to TiO2 film for improvement of biocompatibility

In this work, using a bio-chemical modification method, collagen type I was immobilized on the TiO2 film surface by a silane coupling reagent of aminopropyltriethoxysilane. X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy were used to investigate the characteristics of the modified TiO2 film. The thrombus formation ability of the films was studied by in vitro platelet adhesion test. Furthermore, the biological behavior of cultured human umbilical vein endothelial cells (HUVECs) onto different films was investigated by in vitro HUVECs cultured experiment. The results show that the modification can improve the biocompatibility of TiO2 film for applications of biomedical microcoil hemangioma treatment, etc.